Endothelial progenitor obsolescence and atherosclerotic inflammation.

Voluntary running suppresses proinflammatory cytokines and bone marrow endothelial progenitor cell levels in apolipoprotein-E-deficient mice.

Long-term exercise is associated with reduced atherosclerotic burden, inflammation, and enhanced endothelial progenitor cell (EPC) levels in mice. Infusion of progenitor cells in mice decreases atherosclerosis and suppresses inflammation. The aim of this study was to determine whether exercise-induced enhancement of EPCs is associated with reduced atherosclerosis and inflammation. To study this...

The Effect of Combining Resistance Training and Endothelial Progenitor Cell Injection on the Expression of Angiogenic Factors In Diabetic Male Rats Induced By Stz

Background: Angiogenesis disorders are known mechanisms of diabetes. With the aim of reducing angiogenesis disorders, resistance training and its combination with endothelial progenitor cell injection are new strategies. Therefore, the present study was performed to determine the effect of resistance training with endothelial progenitor cell injection on the expression of angiogenic factors in ...

Platelets, inflammation and atherosclerosis.

An expanding body of evidence continues to build on the role of platelets as initial actors in the development of atherosclerotic lesions. Platelets bind to leukocytes and endothelial cells, and initiate monocyte transformation into macrophages. Platelets internalize oxidized phospholipids and promote foam cell formation. Platelets also recruit progenitor cells to the scene that are able to dif...

Endothelial Progenitor Cell Dysfunction in Polycystic Ovary Syndrome: Implications for The Genesis of Cardiovascular Diseases

Recent Discoveries and Novel Hypotheses

Atherosclerosis is an inflammatory process that selectively affects arteries and is highly prevalent in both women and men. Thrombo-occlusive complications of atherosclerosis, including stroke and myocardial infarction, are major causes of morbidity and mortality. Senescence of the arterial tree is a biological process that follows a natural course that can be accelerated by the combined injury...